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Yeudall WA et al (2012) Gain-of-function mutant p53 upregulates CXC chemokines andenhances cell migration.
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The ?rst structure ofthe p53 DBD in complex with DNA classi?ed the most-commonly found cancermutations in two groups, as either affecting direct DNA recognition (so called“contact mutants”, for example: Arg248 or Arg 273) or destabilizing the twoloops and the loop-sheet-helix motif involved in DNA binding (so called “struc-tural mutants”, for example: Arg175, Gly245, Arg 249, or Arg282) [ 14 ].
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